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Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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Related Experiment Video

Updated: Apr 7, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Microparticles and endothelial function--A tour de force

Victor A Ferraris¹

¹Department of Surgery, University of Kentucky, Lexington, Ky.

The Journal of Thoracic and Cardiovascular Surgery

|July 12, 2015

Summary

No abstract available in PubMed .

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