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Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users.

Marc J W Lammers1,2, Ruben H M van Eijl3,4, Gijsbert A van Zanten5,6

  • 1Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Room G.02.531, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. m.j.w.lammers-2@umcutrecht.nl.

Journal of the Association for Research in Otolaryngology : JARO
|July 12, 2015
PubMed
Summary

Early-onset deafness in children impairs auditory brainstem maturation, even after cochlear implant (CI) use. Delayed brainstem responses in prelingually deaf adults suggest impaired maturation, impacting speech perception outcomes.

Keywords:
auditory brainstem responsecochlear implantdeafnesshearing losshumansmaturationprelingual deaf

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Area of Science:

  • Neuroscience
  • Audiology
  • Developmental Biology

Background:

  • Severe early-onset hearing loss can hinder auditory brainstem development.
  • Most research focuses on children's auditory brainstem activation with cochlear implants (CIs).
  • Limited data exists on adult CI users with prelingual deafness.

Purpose of the Study:

  • To compare auditory brainstem activation in prelingually deaf adult CI users versus postlingually deaf CI users.
  • To investigate the impact of early-onset deafness on auditory brainstem maturation in adult CI recipients.

Main Methods:

  • Recording electrically evoked auditory brainstem responses (eABRs) using monopolar stimulation.
  • Utilizing both middle and apical electrodes of the cochlear implant (CI).
  • Analyzing wave V and III-V interwave latencies in different CI user groups.

Main Results:

  • Wave V latencies were significantly delayed in prelingually deaf CI users for both electrode locations.
  • The III-V interwave interval was longer in prelingually deaf individuals when stimulating the apical electrode.
  • These delays suggest slower neural conduction due to impaired maturation from prolonged early hearing loss.

Conclusions:

  • Prelingual deafness and prolonged hearing loss in infancy likely impair auditory brainstem maturation in adult CI users.
  • More mature brainstem function, indicated by shorter wave V latencies, may predict better speech perception outcomes.
  • Understanding these developmental impacts is crucial for optimizing auditory rehabilitation strategies.