Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.8K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

34.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.4K
Epigenetic Regulation01:46

Epigenetic Regulation

26.3K
26.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.7K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.9K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Catastrophic antiphospholipid syndrome in a 39-year-old woman.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

A Rare Large-Artery Complication of Cryoglobulinemia: Superior Gluteal Artery Pseudoaneurysm.

JACC. Case reports·2026
Same author

Successful Treatment of Bullous Pyoderma Gangrenosum With Dapsone.

American journal of therapeutics·2026
Same author

Multisystem Complications in Postpartum-Onset Evans Syndrome: A Case Report.

Cureus·2026
Same author

The Role of GLP-1 Agonists in Psoriatic Arthritis: Erratum.

American journal of therapeutics·2026
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
Same journal

The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies.

Seminars in immunopathology·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.1K

Epigenetics and systemic sclerosis.

Nezam Altorok1, Bashar Kahaleh

  • 1Division of Rheumatology, Department of Internal Medicine, University of Toledo Medical Center, 3000 Arlington Ave., Mailstop 1186, Toledo, OH, 43614, USA, nezam.altorok@utoledo.edu.

Seminars in Immunopathology
|July 12, 2015
PubMed
Summary
This summary is machine-generated.

Environmental factors may trigger epigenetic changes, like DNA methylation and microRNAs, contributing to Systemic Sclerosis (SSc) development. This review explores epigenetics in SSc pathogenesis, highlighting non-genetic influences over genetic risk.

More Related Videos

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

8.0K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

19.1K

Related Experiment Videos

Last Updated: Apr 7, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.1K
Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

8.0K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

19.1K

Area of Science:

  • Immunology
  • Genetics
  • Environmental Health

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease involving vascular injury, immune activation, and fibrosis.
  • Its exact cause is unknown, but environmental factors are implicated in its pathogenesis.
  • Epigenetic mechanisms (DNA methylation, histone modifications, microRNAs) mediate gene expression in response to environmental stimuli.

Purpose of the Study:

  • To review current understanding of epigenetic regulation in Systemic Sclerosis.
  • To discuss environmental factors and mechanisms contributing to epigenetic dysregulation in SSc.

Main Methods:

  • Literature review of studies on epigenetics and Systemic Sclerosis.
  • Analysis of epigenetic mechanisms including DNA methylation, histone modifications, and microRNAs.
  • Examination of the interplay between environmental exposures and genetic predisposition in SSc.

Main Results:

  • Non-genetic factors play a significant role in SSc, potentially outweighing genetic risk.
  • Epigenetic regulation acts as a molecular link between environmental exposures and disease development.
  • Emerging evidence suggests a crucial role for epigenetics in the SSc phenotype.

Conclusions:

  • Epigenetic dysregulation is a key factor in Systemic Sclerosis pathogenesis.
  • Environmental factors likely trigger epigenetic modifications that contribute to SSc.
  • Further research into SSc epigenetics may reveal novel therapeutic targets.