Jove
Visualize
Contact Us

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

186
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
186
Allergic Reactions02:06

Allergic Reactions

33.9K
Overview
33.9K
Cross-reactivity00:42

Cross-reactivity

34.0K
Overview
34.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

8.4K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same author

IgE Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges.

Allergy·2026
Same author

Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test.

Allergy·2026
Same author

Age-Appropriate Low Dosing for Food Protein-Induced Enterocolitis Syndrome Oral Food Challenges: Proposing a Standardized Approach.

The journal of allergy and clinical immunology. In practice·2026
Same author

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward.

Allergy·2026
Same author

The Evolution of Sesame Seed Allergy Over Time.

Allergy·2026
Same journal

AMPK-driven immunometabolic reprogramming enhances CD19<sup>+</sup>CD21<sup>hi</sup>CD24<sup>hi</sup> regulatory B cell-mediated suppression of atopic dermatitis.

The Journal of allergy and clinical immunology·2026
Same journal

Corrigendum.

The Journal of allergy and clinical immunology·2026
Same journal

Comparative Efficacy of Biologic Agents for Severe Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Network Meta-analysis.

The Journal of allergy and clinical immunology·2026
Same journal

Tamoxifen-driven neutrophil reprogramming protects from pulmonary Granulibacter bethesdensis infection in chronic granulomatous disease.

The Journal of allergy and clinical immunology·2026
Same journal

Clinical and transcriptomic characterization of mixed granulocytic COPD phenotype.

The Journal of allergy and clinical immunology·2026
Same journal

Dupilumab outcomes in pediatric asthma by early eosinophil status: post hoc analysis of VOYAGE/EXCURSION.

The Journal of allergy and clinical immunology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 7, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

International consensus on allergy immunotherapy.

Marek Jutel1, Ioana Agache2, Sergio Bonini3

  • 1Department of Clinical Immunology, Wrocław Medical University, and "ALL-MED" Medical Research Institute, Wrocław, Poland.

The Journal of Allergy and Clinical Immunology
|July 12, 2015
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy (AIT) is an effective treatment for allergies but remains underused globally. Developing a broader consensus is crucial to improve AIT practices and its accessibility for patients worldwide.

Keywords:
International consensusallergen vaccineallergic rhinitisallergyasthmaatopic dermatitisfood allergyimmunotherapy

More Related Videos

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

17.1K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.2K

Related Experiment Videos

Last Updated: Apr 7, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

17.1K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.2K

Area of Science:

  • Allergy and Immunology
  • Immunotherapy Research

Background:

  • Allergen immunotherapy (AIT) has been available since the early 1900s and proven effective for allergic rhinitis and asthma.
  • Despite proven efficacy, AIT is underused globally (<10% of patients) with significant regional disparities.
  • Indications for AIT in atopic dermatitis and food allergy require further definition.

Purpose of the Study:

  • To address the underutilization and inconsistent application of Allergen Immunotherapy (AIT).
  • To foster a global consensus on best practices for AIT.
  • To harmonize, disseminate, and implement optimal AIT strategies internationally.

Main Methods:

  • Review of existing clinical trials and meta-analyses on AIT efficacy.
  • Analysis of current guidelines and consensus documents.
  • Formation of an international collaboration (ICAAI) to develop a comprehensive consensus report.

Main Results:

  • AIT is the only treatment capable of altering the course of allergic disease, preventing asthma development, and inducing immune tolerance.
  • Ongoing development of safer and more effective AIT strategies, including new allergen preparations, adjuvants, and administration routes.
  • Significant need for international harmonization and dissemination of AIT best practices.

Conclusions:

  • AIT is a disease-modifying treatment with potential beyond symptom control.
  • Standardizing AIT approaches globally is essential for wider adoption and improved patient outcomes.
  • International collaboration is key to advancing the field of AIT.