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H2S: A New Approach to Lifespan Enhancement and Healthy Ageing?

Bedoor Qabazard1, Stephen R Stürzenbaum

  • 1MRC-HPA Centre for Environment and Health, Analytical and Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.

Handbook of Experimental Pharmacology
|July 12, 2015
PubMed

Insights

Hydrogen sulfide (H2S) may regulate cell fate and the ageing process. Research in the nematode C. elegans explores H2S

Area of Science:

  • Biogerontology
  • Molecular Biology
  • Cellular Aging

Background:

  • Aging is a primary risk factor for numerous age-related diseases, including neurodegenerative disorders and cancer.
  • Biogerontology seeks drug targets to slow aging and promote healthy aging, delaying disease onset.
  • Hydrogen sulfide (H2S) exhibits protective cellular functions: antioxidant, anti-inflammatory, and cytoprotective effects.

Purpose of the Study:

  • To review the current understanding of hydrogen sulfide's role in the aging process.
  • To investigate H2S involvement in aging, focusing on the model organism C. elegans.

Main Methods:

  • Literature review of existing research on H2S and aging.
  • Focus on studies utilizing the nematode Caenorhabditis elegans as a model system.

Main Results:

  • H2S acts as a signaling molecule, neuromodulator, and cytoprotectant.
  • H2S has been shown to regulate cell cycle and survival in healthy cells.
  • These regulatory functions suggest a potential role for H2S in controlling cell fate and aging.

Conclusions:

  • Hydrogen sulfide (H2S) may play a significant role in regulating cellular aging.
  • Further research in model organisms like C. elegans is crucial to elucidate H2S mechanisms in aging.
  • Understanding H2S's impact on aging could lead to novel therapeutic strategies for age-related diseases.

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