Dynamics of serotype 14 Streptococcus pneumoniae population causing acute respiratory infections among children in

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Mingming He1, Kaihu Yao2, Wei Shi3

  • 1Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, P. R. China. ming1219ming@163.com.

BMC Infectious Diseases
|July 12, 2015
PubMed
Abstract

Insights

The prevalence of Streptococcus pneumoniae serotype 14 increased in China, linked to rising antibiotic resistance. Clonal complex 876 (CC876) emerged, driving increased resistance to beta-lactam antibiotics.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Antibiotic abuse has altered Streptococcus pneumoniae populations.
  • Serotype 14 isolates from children with respiratory infections in China were studied.
  • The study period spanned 1997-2012.

Purpose of the Study:

  • Determine the genetic structure of S. pneumoniae serotype 14 isolates.
  • Investigate antibiotic resistance patterns and genetic relatedness.
  • Analyze the evolution of S. pneumoniae serotype 14 in China.

Main Methods:

  • Antibiotic susceptibility testing using E-test or disc diffusion.
  • Detection of macrolide resistance genes (ermB, mefA) and DHFR gene via PCR.
  • Multilocus sequence typing (MLST) for sequence type (ST) and clonal complex (CC) analysis.

Main Results:

  • Serotype 14 S. pneumoniae prevalence increased from 1997-2012.
  • All isolates were susceptible to amoxicillin-clavulanic acid, vancomycin, and levofloxacin.
  • Erythromycin resistance was high (143/144 isolates), associated with ermB and mefA.
  • Non-susceptibility to cephalosporins and trimethoprim increased.
  • CC876 became dominant (96.4% by 2010-2012), replacing CC875.
  • CC876 exhibited higher non-susceptibility to beta-lactam antibiotics than CC875.

Conclusions:

  • Serotype 14 S. pneumoniae isolates increased in China.
  • The rise in beta-lactam antibiotic resistance is linked to the spread of CC876.
  • CC876 is associated with increased antimicrobial resistance in S. pneumoniae serotype 14.

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