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Engineering antigen-specific immunological tolerance
Stephan Kontos1, Alizée J Grimm2, Jeffrey A Hubbell3
1Anokion SA, Ecublens, Switzerland.
Current Opinion in Immunology
|July 12, 2015
Summary
New strategies using engineered molecules harness peripheral tolerance mechanisms to prevent or reverse unwanted immune responses. These antigen-specific approaches are advancing towards clinical applications for various immune-related conditions.
Area of Science:
- Immunology
- Biotechnology
- Drug Development
Background:
- Unwanted immune responses are common in protein drug therapy, autoimmunity, allergies, and transplantation.
- Current strategies focus on preventing or reversing these immune responses.
Purpose of the Study:
- To present recent advancements in inducing antigen-specific immunological tolerance.
- To highlight engineered biomolecules that leverage peripheral tolerance mechanisms.
Main Methods:
- Utilizing engineered peptides, proteins, and biomaterials.
- Harnessing peripheral tolerance mechanisms, including B and T lymphocyte responses.
- Inducing cellular deletion, ignorance, or active immune regulation.
Main Results:
- Demonstrated successful induction of antigen-specific immunological tolerance.
- Engineered molecules effectively modulate immune responses prophylactically and therapeutically.
Conclusions:
- Engineered biomolecules offer promising avenues for inducing antigen-specific tolerance.
- Several approaches are progressing to clinical trials, indicating therapeutic potential.
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