Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

44.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.9K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

2.2K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
2.2K
Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

4.3K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synucleinopathy-like clinical features and biologically defined synuclein seeding in PSP-Parkinsonism: an imperfect match.

NPJ Parkinson's disease·2026
Same author

Rapid Eye Movement Sleep Behavior Disorder with Clinical Dementia with Lewy Bodies Phenotype but Lacking Postmortem Central Nervous System Synuclein Pathology: Alternate Etiologies.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Efficacy of Deep Brain Stimulation for the Treatment of Monogenic Dystonia Symptoms: A Systematic Review.

European journal of neurology·2026
Same author

Brainstem pathology in anti-IgLON5 disease: new insights into early events and tau progression.

Brain : a journal of neurology·2026
Same author

A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing human brain.

Epilepsia·2026
Same author

Variably Protease-Sensitive Prionopathy: Two New Cases With Motor Neuron-Dementia Syndrome.

Annals of clinical and translational neurology·2025
Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026
Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026
Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026
Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026
Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026
Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development
07:54

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

12.0K

Alpha-synuclein immunoreactivity patterns in the enteric nervous system.

Iban Aldecoa1, Judith Navarro-Otano2, Nadia Stefanova3

  • 1Department of Pathology, Barcelona, Spain.

Neuroscience Letters
|July 12, 2015
PubMed
Summary
This summary is machine-generated.

Investigating alpha-synuclein (α-syn) in the gut, this study found that coarse aggregates in neural structures are the most promising diagnostic marker for Lewy-body parkinsonism in gastrointestinal tissues.

Keywords:
Alpha-synucleinEnteric nervous systemGastrointestinal tractLewy pathologyParkinson disease

More Related Videos

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
11:53

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

17.8K
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.8K

Related Experiment Videos

Last Updated: Apr 7, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development
07:54

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

12.0K
Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
11:53

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

17.8K
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.8K

Area of Science:

  • Neuropathology
  • Gastroenterology
  • Immunohistochemistry

Background:

  • Alpha-synuclein (α-syn) pathology in the gastrointestinal tract is increasingly recognized in Parkinson disease (PD).
  • Different antibodies targeting α-syn may yield varying results due to epitope and protein state recognition.
  • Standardized diagnostic markers for PD in the gut are needed.

Purpose of the Study:

  • To compare the immunoreactivity patterns of four distinct anti-α-syn antibodies.
  • To evaluate these patterns in surgical specimens from the gastrointestinal tract of Parkinson disease (PD) and control cases.
  • To identify the most reliable α-syn marker for diagnosing Lewy-body parkinsonism in the gut.

Main Methods:

  • Surgical specimens (stomach, small and large bowel) from 6 PD cases and 12 controls were analyzed.
  • Four primary antibodies were used: anti-α-syn clone KM51, anti-phosphorylated α-syn Ser129, anti-α-syn clone 15G7, and anti-nitrated α-syn505.
  • Immunoreactivity patterns were characterized and compared across antibodies and patient groups.

Main Results:

  • Distinct immunoreactivity patterns were observed: coarse Lewy-body-like aggregates (4/6 PD, 1/12 controls), punctate cytoplasmic staining (3/6 PD, 3/12 controls), and fine diffuse synaptic staining (all subjects).
  • Coarse aggregates were detected primarily in PD cases, while diffuse staining was present in all subjects.
  • The anti-phosphorylated α-syn antibody showed distinct punctate staining in a subset of both PD and control cases.

Conclusions:

  • Different anti-α-syn antibodies recognize distinct epitopes and protein states, leading to varied immunoreactivity patterns in gastrointestinal specimens.
  • Coarse, Lewy-body-like aggregates in neural structures represent the most promising biomarker for diagnosing Lewy-body parkinsonism in the gastrointestinal tract.
  • Further validation is needed to establish the diagnostic utility of specific α-syn aggregates in gut biopsies for PD.