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[Anti-fibrinogen antibodies in chronic diseases of the liver]
The authors investigated the presence of antifibrinogen antibodies (PFb) in the blood of patients with chronic liver diseases (n = 75) and in healthy persons (n = 24). PFb was determined by means of passive haemagglutination reaction of human group 0, Rh minus blood cells enveloped by fibrinogen cleared chromatographically. PFb were directed against fragments D of fibrinogen (immunoblotting method). In hepatocirrhosis PFb appeared in 52% of cases, in chronic hepatitis--in 40.6%, in simple fatty degeneration of the liver--in 33.3%, and in control group only in one person (4.2%). Average concentration of PFb increased as hepatic damage increased. No correlation was found between the presence of PFb and the concentration of fibrinogen and fibrinolytic activity of the plasma. PFb were found significantly more common and in higher concentrations in patients with positive test results of EGT, SDPS and SCT, which indicates to a connection between a latent syndrome of intravascular clotting and the presence of PFb in liver diseases. The results of the examination confirm a hypothesis about the importance of antigenic neodeterminants revealing as a result of proteolytic fibrinogen degradation (fragments D) in inducing PFb.
The authors investigated the presence of antifibrinogen antibodies (PFb) in the blood of patients with chronic liver diseases (n = 75) and in healthy persons (n = 24). PFb was determined by means of passive haemagglutination reaction of human group 0, Rh minus blood cells enveloped by fibrinogen cleared chromatographically. PFb were directed against fragments D of fibrinogen (immunoblotting method). In hepatocirrhosis PFb appeared in 52% of cases, in chronic hepatitis--in 40.6%, in simple fatty degeneration of the liver--in 33.3%, and in control group only in one person (4.2%). Average concentration of PFb increased as hepatic damage increased. No correlation was found between the presence of PFb and the concentration of fibrinogen and fibrinolytic activity of the plasma. PFb were found significantly more common and in higher concentrations in patients with positive test results of EGT, SDPS and SCT, which indicates to a connection between a latent syndrome of intravascular clotting and the presence of PFb in liver diseases. The results of the examination confirm a hypothesis about the importance of antigenic neodeterminants revealing as a result of proteolytic fibrinogen degradation (fragments D) in inducing PFb.