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Single dose pharmacokinetics of calcium antagonist nifedipine in ethanol dependent rats
1Department of Experimental and Clinical Pharmacology, Medical Academy, Warszawa, Poland.
Polish Journal of Pharmacology and Pharmacy
|May 1, 1989
Abstract:
The single dose (6 mg/kg, iv) kinetic study of calcium antagonist nifedipine was performed in plasma and brain tissue of control rat and after single and prolonged treatment with ethanol. The prolonged administration of ethanol for 6 weeks lowered the plasma concentration of nifedipine and decreased its penetration into the brain tissue. The opposite effects were shown in rats treated with ethanol for 6 months.