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Related Experiment Video

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The Role of Anatomical Dissection in Defining Colic and Small Bowel Artery Lymphovascular Bundles in the D3 Volume of Small and Large Bowel Mesentery
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Mesocolic Lymph Node Number, Size, and Density: An Anatomical Study.

Omid Ahmadi1, John L McCall, Mark D Stringer

  • 11 Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand 2 Department of Anatomy, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand 3 Department of Paediatric Surgery, University of Otago, Christchurch, New Zealand.

Diseases of the Colon and Rectum
|July 13, 2015
PubMed
Summary

This study found the sigmoid mesocolon has a median of 71 lymph nodes, while the ascending mesocolon has 61. Ascending lymph nodes are larger, impacting colon cancer staging and prognosis.

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Area of Science:

  • Anatomical studies
  • Surgical oncology
  • Colorectal cancer research

Background:

  • Lymph nodes are crucial for colon cancer staging, treatment, and prognosis.
  • The normal number and morphology of lymph nodes in the mesocolon are not well-defined.

Purpose of the Study:

  • To investigate the number and size of lymph nodes in the ascending and sigmoid mesocolons.
  • To provide anatomical data relevant to colon cancer interpretation.

Main Methods:

  • Descriptive anatomical cadaver study.
  • Examination of 10 sigmoid and 5 ascending mesocolons.
  • Systematic histological sectioning to analyze lymph node number, size, and appearance.

Main Results:

  • Median lymph node counts: 71 in sigmoid, 61 in ascending mesocolon.
  • Ascending mesocolic lymph nodes were significantly larger (median 2.1 mm) than sigmoid nodes (median 1.6 mm).
  • Over 90% of lymph nodes were less than 5 mm; 30% showed fatty replacement.

Conclusions:

  • Established median lymph node counts for sigmoid and ascending mesocolons.
  • Highlighted significant size differences between lymph nodes in these regions.
  • Findings are pertinent for interpreting lymph node yields in colon cancer surgery.