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Impact of Patient Age on Procedure Type for Ulcerative Colitis: A National Study
Jessica N Cohan1, Peter Bacchetti, Madhulika G Varma
11 Philip R. Lee Institute for Health Policy Studies and Department of Surgery, University of California, San Francisco, San Francisco, California 2 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 3 Section of Colorectal Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California.
Background:
Historically, older patients with ulcerative colitis were not considered candidates for ileal pouch-anal anastomosis. However, more recent evidence suggests that this procedure can be performed in older patients with acceptable surgical and functional results.
Objective:
The purpose of this work was to determine whether older age is independently associated with surgical procedure type among patients with ulcerative colitis in a large national database.
Design:
This was a cross-sectional analysis of ulcerative colitis patients undergoing end ileostomy or IPAA, grouped by age.
Settings:
This study was conducted in a university teaching hospital.
Patients:
Patients with ulcerative colitis who underwent total proctocolectomy or completion proctectomy with either IPAA or end ileostomy from 2005 to 2012 in the American College of Surgeons National Surgery Quality Improvement Program database were included in this study.
Main Outcome Measures:
The primary outcome was procedure type (end ileostomy or IPAA). Patient factors associated with procedure type, including age and trends over time, were examined using multivariate logistic regression.
Results:
Among 3635 patients with ulcerative colitis, 28.2% underwent end ileostomy and 71.8% underwent IPAA. Older patients were more likely to undergo end ileostomy than patients ≤50 years of age after adjustment for sex, smoking, BMI, frailty trait count, and ASA class (p < 0.001). The odds of end ileostomy decreased by 12% per year between 2005 and 2012 in patients aged 61 to 70 years compared with patients ≤50 years of age (adjusted OR, 0.88 per year; p = 0.021).
Limitations:
We were unable to analyze other potentially important determinants of procedure type, such as surgeon, patient preference, and anal sphincter integrity.
Conclusions:
Age remains strongly associated with procedure type. The use of end ileostomy, however, is decreasing over time in patients 61 to 70 years of age as evidence accumulates that IPAA is an acceptable option for older patients with ulcerative colitis (see Video, Supplemental Digital Content 1, http://links.lww.com/DCR/A191).
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