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Published on: August 9, 2022
Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical
Abdelkader Mouri1, Olivier Diat2, Abdeslam El Ghzaoui3
1Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France; Medesis Pharma, S.A, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
Abstract:
The phase behavior of the four-components Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol® ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L2) as well as an inverted hexagonal (H2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.
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