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Systemic IgG4-related disease presents diversely, often mimicking other conditions. This report details two cases initially misdiagnosed as acute cholecystitis and pancreatic cancer.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Oncology

Background:

  • Systemic IgG4-related disease (IgG4-RD) is a multisystem fibroinflammatory condition.
  • IgG4-RD can present with a wide range of clinical manifestations.
  • Its presentation can often mimic other distinct disease entities, leading to diagnostic challenges.

Observation:

  • This report describes two patients with IgG4-RD.
  • The first patient presented with symptoms initially suggestive of acute cholecystitis.
  • The second patient was initially diagnosed with metastatic pancreatic adenocarcinoma and peritoneal metastasis.

Findings:

  • Both patients were ultimately diagnosed with IgG4-related disease.
  • The findings highlight the potential for IgG4-RD to be misdiagnosed.
  • The diverse clinical presentations underscore the importance of considering IgG4-RD in differential diagnoses.

Implications:

  • Accurate and timely diagnosis of IgG4-RD is crucial for appropriate management.
  • Increased awareness of IgG4-RD's mimicry can improve patient outcomes.
  • Further research into differentiating IgG4-RD from other conditions is warranted.