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Published on: August 15, 2016
A cyclodextrin-based polymer for sensing diclofenac in water
Pu Xiao1, Nicolas Weibel2, Yves Dudal3
1School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Abstract:
An assay for the determination of diclofenac concentration, in the micromolar range in water, was developed. It is based on the use of a recently developed cyclodextrin-based polymer that possesses an inherent affinity for the target pharmaceutical. This competitive assay is exploiting the possibility to displace a fluorescent dye, adsorbed in the cyclodextrin-based polymer, by the target drug. This displacement is followed by measuring the increase in fluorescence polarization of the dye released in solution. The assay was successfully tested on a real wastewater sample with a limit of detection of 1 μM.
