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A cyclodextrin-based polymer for sensing diclofenac in water.

Pu Xiao1, Nicolas Weibel2, Yves Dudal3

  • 1School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, New South Wales 2052, Australia.

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Summary

A new assay detects diclofenac in water using a cyclodextrin-based polymer. This method quantifies the pharmaceutical in the micromolar range, offering a sensitive tool for environmental monitoring.

Keywords:
Cyclodextrin-based polymerDiclofenacFluorescent polarizationWastewater

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Area of Science:

  • Environmental Chemistry
  • Analytical Chemistry
  • Polymer Science

Background:

  • Diclofenac is a widely used pharmaceutical agent.
  • Accurate determination of diclofenac in environmental samples is crucial for monitoring water quality.
  • Existing analytical methods may require complex procedures or expensive equipment.

Purpose of the Study:

  • To develop a novel, sensitive assay for diclofenac determination.
  • To utilize a cyclodextrin-based polymer for selective pharmaceutical detection.
  • To establish a cost-effective and efficient method for environmental analysis.

Main Methods:

  • Development of a competitive fluorescence polarization assay.
  • Utilizing a cyclodextrin-based polymer with inherent affinity for diclofenac.
  • Measuring the displacement of a fluorescent dye by diclofenac.

Main Results:

  • The assay successfully determined diclofenac concentration in the micromolar range.
  • A limit of detection of 1 μM was achieved for diclofenac.
  • The assay demonstrated effectiveness when tested on a real wastewater sample.

Conclusions:

  • A novel cyclodextrin-based polymer assay provides a sensitive method for diclofenac detection.
  • The developed assay is suitable for analyzing diclofenac in environmental water samples.
  • This assay offers a promising tool for pharmaceutical pollution monitoring.