Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

11.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
11.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel compound heterozygous mutations identified in ADAMTSL4 gene in a Chinese family with isolated ectopia lentis.

Acta ophthalmologica·2014
Same author

Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Lancet (London, England)·2014
Same author

Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Lancet (London, England)·2014
Same author

Diabetic retinopathy and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011.

PloS one·2014
Same author

Ophthalmology: potential future developments in China and worldwide.

Chinese medical journal·2014
Same author

Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys.

Investigative ophthalmology & visual science·2014

Related Experiment Video

Updated: Apr 7, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Choroidal physiology and primary angle closure disease.

Xiulan Zhang1, Wei Wang1, Tin Aung2

  • 1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.

Survey of Ophthalmology
|July 13, 2015
PubMed
Summary

Primary angle closure disease (PACD) involves choroidal thickening. New imaging technologies help understand the choroid's role in PACD development and progression.

Keywords:
angle-closure glaucomachoroidal thicknessglaucomaoptical coherence tomographypathogenesis

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.8K
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.5K

Related Experiment Videos

Last Updated: Apr 7, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.8K
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.5K

Area of Science:

  • Ophthalmology
  • Anatomy
  • Pathophysiology

Background:

  • Primary angle closure disease (PACD) is common in Asian populations, linked to anatomical factors like shallow anterior chambers and shorter axial lengths.
  • Physiological factors, particularly choroidal thickening, are increasingly recognized for their role in triggering acute PACD.
  • Recent advancements in imaging, including enhanced depth imaging (EDI) and swept-source optical coherence tomography (SS-OCT), have improved visualization of choroidal changes.

Purpose of the Study:

  • To review the choroid's functions and its changes in the pathogenesis of PACD.
  • To discuss the contribution of novel imaging technologies to understanding PACD.
  • To explore potential future research directions regarding the choroid in PACD.

Main Methods:

  • Literature review focusing on studies investigating choroidal changes in PACD.
  • Analysis of research utilizing advanced optical coherence tomography (OCT) techniques.
  • Synthesis of current understanding of choroidal pathophysiology in relation to PACD.

Main Results:

  • Choroidal thickening is a consistent finding in both treated and untreated PACD, across acute and chronic forms.
  • Advanced OCT imaging has provided detailed insights into choroidal morphology and its alterations in PACD.
  • The choroid plays a significant, though not fully elucidated, role in the development and progression of PACD.

Conclusions:

  • The choroid is a key anatomical structure implicated in PACD.
  • Emerging imaging technologies are crucial for further understanding the choroid's role in PACD.
  • Future research should focus on the specific mechanisms by which choroidal changes contribute to PACD.