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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Related Experiment Video

Updated: Apr 7, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
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Non-IgE mediated mast cell activation.

Yingxin Yu1, Bart R Blokhuis1, Johan Garssen1

  • 1Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

European Journal of Pharmacology
|July 13, 2015
PubMed
Summary
This summary is machine-generated.

Mast cells, key players in allergies, can be activated by non-IgE stimuli. This review explores diverse triggers beyond immunoglobulin E (IgE) that activate mast cells and mediate allergic responses.

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are central to allergic reactions, primarily triggered by immunoglobulin E (IgE).
  • Mast cell degranulation and mediator release are complex processes influenced by multiple factors.
  • Beyond IgE, various stimuli can modulate mast cell functions.

Purpose of the Study:

  • To review current knowledge on non-IgE mediated mast cell activation.
  • To highlight the diverse range of stimuli that trigger mast cell degranulation and mediator release.
  • To discuss the implications of mast cell versatility in physiological and pathological conditions.

Main Methods:

  • Literature review of scientific articles on mast cell activation.
  • Analysis of studies investigating non-IgE mediated mast cell responses.
  • Synthesis of current understanding on mast cell stimuli and functions.

Main Results:

  • Mast cells respond to a wide array of non-IgE stimuli, including IgG, complement components, and various signaling molecules.
  • These stimuli can induce direct degranulation, selective mediator release, proliferation, differentiation, and migration.
  • Synergistic effects between non-IgE stimuli and IgE-mediated activation are observed.

Conclusions:

  • Mast cells are versatile immune cells activated by numerous non-IgE pathways.
  • Understanding these diverse stimuli is crucial for comprehending mast cell roles in health and disease.
  • Non-IgE pathways offer potential targets for therapeutic interventions in allergic and inflammatory conditions.