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Updated: Apr 7, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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[Cardiac Resynchronization Therapy in the Treatment of Heart Failure in Children]

J Janoušek, I A Kovalev, P Kubuš

    Kardiologiia
    |July 14, 2015
    PubMed

    Insights

    Cardiac resynchronization therapy (CRT) shows promise for pediatric heart failure, particularly in cases of complete atrioventricular block with dyssynchrony. However, dilated cardiomyopathy and advanced heart failure predict poor outcomes, necessitating careful patient selection for effective CRT in children.

    Area of Science:

    • Pediatric Cardiology
    • Electrophysiology
    • Heart Failure Management

    Context:

    • Cardiac resynchronization therapy (CRT) is a key treatment for adult heart failure.
    • Limited data and unclear indications exist for pediatric CRT.
    • Pediatric CRT implantation presents unique anatomical and physiological challenges.

    Purpose:

    • To review the pathophysiology of electromechanical dyssynchrony in children.
    • To analyze clinical experience with pediatric CRT.
    • To propose evidence-based indications for pediatric CRT.

    Summary:

    • CRT is most effective in children with heart failure due to right ventricular pacing-induced dyssynchrony and complete atrioventricular block.
    • Dilated cardiomyopathy and advanced heart failure (NYHA class III-IV) are associated with poor CRT response.
    • Epicardial biventricular pacing is recommended for pediatric CRT due to anticipated long-term treatment duration.

    Impact:

    • Clarifies optimal patient selection for pediatric CRT, improving treatment efficacy.
    • Highlights challenges in pediatric CRT device implantation.
    • Provides guidance for future research and clinical practice in pediatric heart failure management.

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