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Updated: Apr 7, 2026
Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
[Assessment of cerebral hemodynamics using computed tomography perfusion in patients with intracranial aneurysms]
Insights
Large intracranial aneurysms (≥16 mm) significantly impair cerebral collateral circulation, especially when thrombosed. CT perfusion imaging is recommended for diagnosing these microcirculatory disorders.
Area of Science:
- Neurology
- Radiology
- Vascular Medicine
Background:
- Intracranial aneurysms can affect cerebral blood flow.
- Collateral circulation is crucial for brain perfusion.
Purpose of the Study:
- To evaluate the impact of intracranial aneurysms on cerebral collateral circulation.
- To correlate these circulatory changes with aneurysm characteristics.
Main Methods:
- CT perfusion and CT angiography were used.
- 41 patients with 47 unruptured intracranial aneurysms were studied.
Main Results:
- Aneurysms <15 mm generally did not impair perfusion.
- Aneurysms >16 mm showed hypoperfusion, increasing with size.
- Thrombosis and aneurysm size, not location, determined hypoperfusion severity.
Conclusions:
- CT perfusion is valuable for aneurysms ≥16 mm.
- It aids in diagnosing microcirculatory and collateral insufficiency.
- Findings can influence treatment decisions.
Objective:
To determine the impact of aneurysm of intracranial arteries on cerebral collateral circulation and to assess the relationship between these changes and the site of the aneurysm.
Material And Methods:
CT perfusion and CT angiography were performed in 41 patients with 47 unruptured intracranial aneurysms of different sites and sizes.
Results:
Impaired perfusion was not found in the majority of the patients with intracranial aneurysms less than 15 mm in diameter. Hypoperfusion in the respective temporal and occipital lobes was noted in 70% of patients with aneurysms greater than 16-25 mm. Generalized hypoperfusion was diagnosed in 100% of patients with aneurysms more than 25 mm, with the partially thrombosed aneurysms accompanied by the severer, irreversible deficit immediately around the aneurysmal sac, which was induced by the effect of volumetric exposure while in the presence of unthrombosed aneurysm, hypoperfusion occasionally involved the cortex of the entire hemisphere. In this investigation, the extent and depth of hypoperfusion depended on the thrombosis of the lumen and the size of an aneurysm rather than the site of the latter.
Conclusion:
CT perfusion may be recommended as a standard examination of patients with detected intracranial aneurysm that is 16 mm or more in size for the timely diagnosis of cortical microcirculatory disorders and collateral circulatory insufficiency, which can affect the choice of a treatment option for the patient.
