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[Whole-body diffusion-weighted magnetic resonance imaging by estimating the measurable diffusion coefficient in
Objective:
To determine whether the measurable diffusion coefficient (MIC) may be used to differentiate normal and lymphomatosis-altered lymph nodes (LNs) in patients with Hodgkin lymphoma (HL).
Material And Methods:
Whole-body magnetic resonance (MR) imaging was used to compare the MICs of LNs in 27 apparently healthy individuals and 41 patients with a verified diagnosis of HL.
Results:
Construction of 95% confidence intervals showed that the MICs of normal LNs were in the range of 1.00 to 1.73 x x10(-3) mm2/sec and significantly higher (p < 0.05) than those of lymphomatosis-affected LNs (MIC, 0.59 to 0.94 x 10(-3) mm2/sec). The cut-off point (for discretization) of normal and lymphomatosis-altered LNs was in the range of 0.94 to 1.00 x 10(-3) mm2/sec. Consequently, the LN with a MIC of less than 0.94 x 10(-3) mm2/sec may be thought of as affected by the lymphomatous process.
Conclusion:
MIC calculation permits differentiation of normal and affected LNs having equal signal characteristics (including those on diffusion-weighted MR images).
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