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[Kampo medicine (rikkunshito)].
Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 14, 2015
Summary
Proton pump inhibitors (PPIs) are standard for gastroesophageal reflux disease (GERD), but some patients are resistant. Rikkunshito, a traditional medicine, may effectively treat PPI-refractory GERD by regulating motility and protecting the esophagus.
Area of Science:
- Gastroenterology
- Pharmacology
- Traditional Japanese Medicine
Context:
- Gastroesophageal reflux disease (GERD) is a prevalent acid-related disorder.
- Proton pump inhibitors (PPIs) are the first-line treatment for GERD according to Japanese guidelines.
- A subset of GERD patients exhibit resistance to PPI therapy, necessitating alternative treatment strategies.
Purpose:
- To investigate the potential of rikkunshito as a treatment for PPI-refractory GERD.
- To explore the mechanisms by which rikkunshito might benefit patients with refractory GERD.
Summary:
- Rikkunshito, a traditional Japanese herbal medicine, is increasingly used adjunctively for PPI-refractory GERD.
- Unlike PPIs, rikkunshito does not inhibit gastric acid secretion.
- Its proposed therapeutic effects stem from its ability to regulate gastrointestinal motility and enhance the esophageal mucosa's physiological integrity against acid exposure.
Impact:
- Rikkunshito offers a potential therapeutic option for GERD patients unresponsive to standard PPI treatment.
- Understanding rikkunshito's mechanisms could lead to novel combination therapies for acid-related disorders.
- This research highlights the value of integrating traditional medicine into modern GERD management.
