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Updated: Apr 7, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
An audit of persistent foramen ovale closure in 105 divers
Alex Pearman1, Luc Bugeja2, Martin Nelson2
1Medical School, University of Bristol, Bristol, UK.
Introduction:
Right-to-left shunt across a persistent foramen ovale (PFO) has been associated with cutaneous, neurological and vestibular decompression illness (DCI). Percutaneous closure of a PFO has been used to reduce the risk of DCI. There are no randomised controlled trial data to support PFO closure for the prevention of decompression illness (DCI), so the need for audit data on the safety and efficacy of this technique has been recognised by the National Institute of Health and Clinical Excellence in the UK.
Method:
Retrospective audit of all transcatheter PFO closures to reduce the risk of DCI performed by a single cardiologist with an interest in diving medicine.
Results:
A total of 105 eligible divers undergoing 107 procedures was identified. There was a low rate of procedural complications; a rate lower than a recent randomised trial of PFO closure for stroke. Atrial fibrillation required treatment in two patients. One patient with a previously repaired mitral valve had a stroke that was thought to be unrelated to the PFO closure. Sixteen divers had minor post-procedure symptoms not requiring any treatment. Two divers required a second procedure because of residual shunt; both subsequently returned to unrestricted diving. Eighty-one of 95 divers in whom follow-up bubble contrast echocardiography was available returned to unrestricted diving.
Conclusions:
The PFO closure procedure appeared to be safe and was associated with the majority of divers being able to successfully return to unrestricted diving.
Insights
Closure of a persistent foramen ovale (PFO) appears safe for divers, with most patients returning to unrestricted diving after the procedure. This audit provides valuable data on PFO closure for decompression illness (DCI) prevention.
Area of Science:
- Cardiology
- Diving Medicine
- Interventional Cardiology
Background:
- Right-to-left shunt across a persistent foramen ovale (PFO) is linked to decompression illness (DCI).
- Percutaneous PFO closure is used to mitigate DCI risk.
- Randomized controlled trial data for PFO closure in DCI prevention are lacking.
Purpose of the Study:
- To audit the safety and efficacy of transcatheter PFO closure for reducing DCI risk in divers.
- To provide audit data on PFO closure, as recognized by the UK's National Institute of Health and Clinical Excellence.
Main Methods:
- Retrospective audit of transcatheter PFO closures performed by a cardiologist specializing in diving medicine.
- Inclusion of 105 divers undergoing 107 procedures for DCI risk reduction.
Main Results:
- Low rate of procedural complications, lower than a trial for stroke prevention.
- Two patients developed atrial fibrillation requiring treatment.
- One stroke occurred, deemed unrelated to PFO closure.
- Two divers needed repeat procedures for residual shunt, but both returned to diving.
- 81 out of 95 divers with follow-up data returned to unrestricted diving.
Conclusions:
- PFO closure is a safe procedure for divers.
- The majority of divers can return to unrestricted diving post-procedure.
- Audit data support the efficacy of PFO closure in this cohort.
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