Restraint stress-induced changes in saccharin preference: the effect of antidepressive treatment and diazepam

The effect of antidepressive treatment and of diazepam on saccharin preference has been studied in a model of acute restraint stress-induced saccharin preference deficit. It has been shown that 1-hr stressor produces short-term, and significant decrease of saccharin preference in a two-bottle test, measured at 24-hr periods of time. Single doses of desipramine and citalopram (10 mg/kg, IP) given prior to stress session significantly attenuated the deficit in saccharin preference. Less strong, but similar effects appeared after postshock antidepressant administration. On the other hand, electroconvulsive shock treatment rather enhanced the depressive influence of the stressor, while diazepam (1 mg/kg, IP) antagonized the suppression of saccharin preference, especially when the drug was given immediately after restraint stress. It is concluded that the acute immobilization-induced decrease in saccharin preference most probably reflects changes in brain emotional processes. The role of disturbances in central motivational mechanisms and its contribution to the effects of antidepressive drugs remains to be established.