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Measuring morphine's capacity to establish a place preference.

L D Reid1, S H Marglin, M E Mattie

  • 1Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.

Pharmacology, Biochemistry, and Behavior
|August 1, 1989
PubMed
Summary
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This study validates an automated 12-chamber system for conditioned place preference (CPP) testing in rats. Optimal session length is 30 minutes, and the system reliably detects morphine-induced CPP.

Area of Science:

  • Behavioral Neuroscience
  • Pharmacology
  • Animal Models

Background:

  • Conditioned place preference (CPP) is a valuable tool for assessing drug reward.
  • Automated systems can enhance the efficiency and standardization of CPP testing.
  • Previous CPP studies have varied in methodology, necessitating validation of new systems.

Purpose of the Study:

  • To assess the validity and reliability of an automated 12-chamber system for CPP testing.
  • To determine optimal parameters for CPP testing within this automated system.
  • To confirm the system's ability to detect drug-induced CPP.

Main Methods:

  • Rats were tested in a 12-chamber automated system.
  • Initial preference, session length effects, and control group stability were evaluated.

Related Experiment Videos

  • Morphine was used to establish a positive CPP, with varied dosing regimens.
  • Exploratory behavior and activity levels were monitored.

    • Main Results:

    • No initial side preference was observed in rats, unaffected by session lengths (15-60 min).
    • Optimal session length was determined to be approximately 30 minutes.
    • The automated system reliably detected morphine-induced CPP.
    • Dosing regimens with unequal conditioning days proved effective and conservative.
    • Exploratory drive is significant and must be managed for CPP emergence.

    Conclusions:

    • The automated 12-chamber system is a valid and reliable tool for CPP testing.
    • Standardized protocols, including a 30-minute session, enhance CPP assessment.
    • The system accurately reflects the rewarding effects of opioids like morphine.