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Added Value of Dual-Time-Point 18F-FDG PET/CT With Delayed Imaging for Detecting Aortic Graft Infection: An
Chih-Yung Chang1, Cheng-Pei Chang, Chun-Che Shih
1From the School of Medicine, National Defense Medical Center, Taipei, Taiwan (C-YC, C-YiC, R-SL); Department of Nuclear Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan (C-YC, C-PC, B-HY, C-WC, L-SC, S-JW, R-SL); Division of Cardiovascular Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan (C-CS); Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan (C-YiC); and Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (C-YC, R-SL).
Dual-time-point F-FDG PET/CT imaging (DTPI) effectively detects aortic graft infections. Delayed imaging improves accuracy and specificity, enhancing visualization of infected graft extent.
Area of Science:
- Nuclear Medicine
- Radiology
- Vascular Surgery
Background:
- Aortic graft infection is a serious complication.
- Early and accurate diagnosis is crucial for patient outcomes.
- F-FDG PET/CT shows promise for detecting graft infections.
Purpose of the Study:
- To evaluate the diagnostic value of dual-time-point F-FDG PET/CT imaging (DTPI) in assessing aortic graft infection.
- To determine if delayed imaging enhances the detection and characterization of infected aortic grafts.
Main Methods:
- Prospective enrollment of 29 patients with suspected aortic graft infection.
- Dual-time-point F-FDG PET/CT imaging with assessment of maximal standardized uptake value (SUVmax) and retention index (RI).
- Image analysis by two nuclear medicine physicians to determine sensitivity, specificity, and accuracy against a reference standard.
Main Results:
- All 5 infected aortic grafts showed positive retention indices (RIs), generally higher than non-infected grafts.
- DTPI detected all infected grafts with improved specificity (88%) and accuracy (90%).
- Delayed imaging improved image quality in 7 patients and provided better delineation of infected graft extent.
Conclusions:
- Non-infected aortic grafts exhibit more variable retention indices compared to infected ones.
- DTPI is a valuable tool for detecting aortic graft infection.
- Delayed imaging in DTPI enhances image quality and the delineation of infected aortic grafts.
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