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Related Experiment Videos

N,N-Dimethyltryptamine-Induced Psychosis.

Neil E Paterson1, W Connor Darby, Preetpal S Sandhu

  • 1*Psychiatry Residency Training Program, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; and †Veterans Affairs West Los Angeles Medical Center, Los Angeles, CA.

Clinical Neuropharmacology
|July 14, 2015
PubMed
Summary

Recreational N,N-dimethyltryptamine (DMT) use can induce psychosis, as seen in a patient who recovered with antipsychotic medication. Increased DMT use may lead to more such cases in emergency departments.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Toxicology

Background:

  • N,N-dimethyltryptamine (DMT) is a potent psychoactive substance acting as a 5-hydroxytryptamine 2A and 1A receptor agonist.
  • Recreational DMT use is increasing, potentially leading to a rise in substance-induced psychoses.
  • This case report details an instance of psychosis linked to repeated DMT consumption.

Observation:

  • A 42-year-old male with no prior psychiatric history presented with psychosis, including disinhibition, elevated affect, disorganized thought, and delusions.
  • The patient reported recent, repeated DMT use and long-term cannabis use.
  • Laboratory tests indicated rhabdomyolysis due to elevated creatinine kinase levels.

Findings:

  • The patient's psychosis resolved within 3 weeks with treatment including quetiapine, divalproex sodium, gabapentin, and hydroxyzine.

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  • Symptoms resolved, and the patient regained insight and judgment.
  • The patient remained symptom-free and compliant with treatment six months post-discharge.

    • Implications:

    • This case highlights substance-induced psychosis from DMT, successfully treated with antipsychotics.
    • Healthcare providers, especially in emergency departments, should anticipate increased cases of DMT-induced psychosis.
    • Early recognition and appropriate pharmacotherapy are crucial for managing DMT-induced psychiatric emergencies.