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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Functions of the Skeletal System01:22

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Bulimia Nervosa01:30

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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Anorexia Nervosa01:28

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Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
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What is the Skeletal System?01:02

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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Updated: Apr 7, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Skeletal complications of eating disorders.

Abigail A Donaldson1, Catherine M Gordon1

  • 1Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, RI.

Metabolism: Clinical and Experimental
|July 14, 2015
PubMed
Summary

Anorexia nervosa (AN) significantly impacts bone health, leading to potential permanent skeletal impairment. This review covers AN

Area of Science:

  • Bone health and skeletal complications in eating disorders.
  • Endocrinology and metabolic bone disease.
  • Psychiatric disorders and their physical sequelae.

Background:

  • Anorexia nervosa (AN) is a severe psychiatric illness with significant medical consequences.
  • Starvation in AN profoundly affects physical health, particularly bone density and integrity.
  • Skeletal complications are a major concern in individuals with AN, potentially leading to long-term impairment.

Purpose of the Study:

  • To review the skeletal complications associated with anorexia nervosa.
  • To provide updates on bone health in AN, considering epidemiological, neuroendocrine, and clinical aspects.
  • To identify knowledge gaps and suggest future research directions in this field.

Main Methods:

  • Comprehensive literature review focusing on skeletal sequelae in eating disorders.
Keywords:
Anorexia nervosaBone healthBone mineral densityEating disorder

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  • Synthesis of current knowledge on epidemiology, neuroendocrine changes, and bone health assessment.
  • Discussion of treatment options and considerations for adolescents versus adults.

    • Main Results:

    • Starvation in AN leads to adverse physical outcomes, including impaired bone health.
    • Specific neuroendocrine changes contribute to skeletal fragility in AN.
    • Adolescent and adult bone health considerations differ, impacting long-term outcomes.

    Conclusions:

    • Anorexia nervosa poses significant risks to skeletal integrity, with potential for irreversible damage.
    • A multidisciplinary approach is crucial for assessing and managing bone health in AN.
    • Further research is needed to address knowledge gaps in understanding and treating skeletal complications of AN.