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Updated: Apr 7, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Near infrared-caged d-amino acids multifunctional assembly for simultaneously eradicating biofilms and bacteria
Weili Wei1, Wei Bing, Jinsong Ren
1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.
Abstract:
A nanodevice composed of an upconverting nanoparticle (UCNP) core and a thin TiO2 shell surface modified with d-amino acids was designed. Due to the UCNP core, NIR light can be converted to high-energy UV photons. As a consequence, UV light can stimulate the TiO2 shell to produce antibacterial reactive oxygen species (ROS) and trigger the release of free d-amino acids (antibiofilm agents).

