Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Necrosis01:16

Necrosis

7.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
7.3K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

5.2K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
5.2K
Sulfur Assimilation01:20

Sulfur Assimilation

506
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
506
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

1.2K
Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
1.2K
Glucose Transporters01:27

Glucose Transporters

28.4K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
28.4K
Translation01:31

Translation

161.5K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
161.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CCC-MMTN: towards robust classification of confusable modulations in few-shot scenarios.

Scientific reports·2026
Same author

Ultrastructural morphometry and genetic divergence of spermatozoa in two morphologically similar Triplophysa species.

Tissue & cell·2026
Same author

Age and Growth of <i>Phoxinus grumi</i> Berg, an Endemic Fish in the Turpan Basin.

Animals : an open access journal from MDPI·2026
Same author

Real Time Pulse Chase (RTPC) In-Cell NMR Spectroscopy Reveals Critical Metabolites in Subminute Metabolism of Undifferentiated and Differentiated Human Neuronal Cells.

Analytical chemistry·2026
Same author

Comment on "Diagnostic Accuracy of Transvaginal Ultrasound for Detecting Pelvic Adhesions and Predicting Surgical Time in Benign Gynecologic Surgery".

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2026
Same author

A chromosomal-level genome assembly of Phoxinus grumi (Cypriniformes: Leuciscidae).

Scientific data·2026

Related Experiment Video

Updated: Apr 7, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

2.2K

Glutaminolysis and Transferrin Regulate Ferroptosis.

Minghui Gao1, Prashant Monian1, Nosirudeen Quadri2

  • 1Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Molecular Cell
|July 14, 2015
PubMed
Summary

Researchers discovered ferroptosis, a form of cell death, is induced by serum factors like transferrin and glutamine. Inhibiting glutaminolysis may treat diseases like heart injury.

More Related Videos

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.5K
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 7, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

2.2K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.5K
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.6K

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Pathology

Background:

  • Ferroptosis is a newly identified regulated necrosis pathway implicated in human diseases.
  • The precise molecular mechanisms driving ferroptosis remain incompletely understood.
  • Existing knowledge gaps hinder the development of targeted therapeutic strategies.

Purpose of the Study:

  • To elucidate the molecular components and mechanisms underlying ferroptosis.
  • To investigate the relationship between ferroptosis, cellular metabolism, and redox balance.
  • To identify potential therapeutic targets for ferroptosis-related conditions.

Main Methods:

  • Induction of ferroptosis via nutrient deprivation (amino acids) in a serum-dependent manner.
  • Identification of key molecular inducers: transferrin and glutamine.
  • Analysis of the roles of the transferrin receptor and glutaminolysis in the ferroptosis pathway.

Main Results:

  • Amino acid deprivation triggers a potent, serum-dependent necrotic process identified as ferroptosis.
  • Transferrin and glutamine were identified as critical serum-derived inducers of ferroptosis.
  • The transferrin receptor and glutaminolysis were confirmed as essential components of the ferroptosis pathway.

Conclusions:

  • Ferroptosis involves specific molecular players including transferrin and glutamine, linking it to cellular metabolism.
  • Inhibition of glutaminolysis, a key pathway in ferroptosis, shows promise in reducing ischemia/reperfusion-induced heart injury.
  • Targeting glutaminolysis presents a potential therapeutic avenue for treating ferroptosis-associated diseases.