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Updated: Apr 7, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and
Katarzyna Gobis1, Henryk Foks1, Katarzyna Wiśniewska2
1Department of Organic Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
Abstract:
A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the α position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal.
Graphical Abstract:
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