Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

5.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
5.0K
T Cell Types and Functions01:24

T Cell Types and Functions

3.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Fretting Corrosion at the Modular Junction of Revision Total Knee Arthroplasty Actually a Problem?

The Journal of arthroplasty·2026
Same author

Establishing bone tissue level changes associated with cognitive impairment.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Visual Representation of Clinical Conditions Across Skin Tones in Nursing Textbooks: A Quantitative Image Analysis.

The American journal of nursing·2026
Same author

Better outcomes of robotic liver resection in segment VII/VIII compared to open and laparoscopic approach.

Journal of robotic surgery·2026
Same author

Holistic determination of ends of cfDNA molecules.

Cell genomics·2026
Same author

Microbial Ecological Signatures Predict Pathogen Emergence and Multidrug Resistance in Cystic Fibrosis Airways up to a Year in Advance.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Apr 7, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

584

Increased Th17/Treg Ratio in Poststroke Fatigue.

Xinjing Liu1, Komal Kenkare2, Shanshan Li3

  • 1Neurology Department, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, Zhengzhou, Henan 450052, China.

Mediators of Inflammation
|July 14, 2015
PubMed
Summary
This summary is machine-generated.

Post-stroke fatigue (PSF) may stem from an immune system imbalance. This study found a higher Th17 to Treg cell ratio in severe fatigue patients, suggesting a potential biomarker for PSF severity.

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.5K

Related Experiment Videos

Last Updated: Apr 7, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

584
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.5K

Area of Science:

  • Immunology
  • Neurology
  • Medical Research

Background:

  • Fatigue is a common and disabling symptom following a stroke.
  • The underlying biological mechanisms of post-stroke fatigue (PFS) remain largely unknown.
  • Understanding PFS mechanisms is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the potential association between T-helper 17 (Th17) and regulatory T (Treg) cell balance and the severity of post-stroke fatigue.
  • To explore the relationship between immune cell populations and fatigue levels in stroke survivors.

Main Methods:

  • Assessed fatigue severity in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC).
  • Categorized participants into severe fatigue and low-moderate fatigue groups using K-mean cluster analysis.
  • Measured peripheral blood Th17 and Treg cell populations and serum interleukin-10 (IL-10) levels.
  • Analyzed differences in immune markers and psychological factors (anxiety, depression) between fatigue groups.

Main Results:

  • No significant differences were observed in demographic or stroke-related factors between fatigue groups.
  • Stroke survivors with severe fatigue reported higher levels of anxiety and depression.
  • A significantly increased ratio of Th17 to Treg cells was found in the severe fatigue group.
  • Serum IL-10 levels showed a negative correlation with the Th17/Treg cell ratio.

Conclusions:

  • Preliminary findings suggest that an imbalance in the Th17/Treg cell ratio is associated with the severity of post-stroke fatigue.
  • This immune dysregulation may represent a key biological mechanism contributing to debilitating fatigue after stroke.
  • Further research is warranted to validate these findings and explore therapeutic interventions targeting immune pathways.