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Giant parietal lobe infantile gliosarcoma in a 5-year-old child
Hemant V Savant1, Srikant Balasubramaniam1, Vijay Mahajan1
1Department of Neurosurgery, BYL Nair Hospital and T.N. Medical College, Mumbai, Maharashtra, India.
Insights
Pediatric gliosarcoma (GSM) is a rare brain tumor. This case study details a 5-year-old girl
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Oncology
Background:
- Gliosarcoma (GSM) is a rare malignant brain tumor in children, representing 1.9% of pediatric glioblastomas.
- Early diagnosis and intervention are crucial for improving outcomes in pediatric central nervous system tumors.
Observation:
- A 5-year-old female presented with fever, loss of appetite, and right-sided weakness.
- MRI revealed a large, heterogeneously enhancing space-occupying lesion in the left parieto-occipital region.
Findings:
- Surgical resection of the parieto-occipital tumor was performed.
- The patient received adjuvant therapy post-surgery.
- Survival was observed for 9 months following the surgical intervention.
Implications:
- This case highlights the challenges in diagnosing and treating pediatric gliosarcoma.
- Further research into the etiopathogenesis and optimal treatment strategies for GSM is warranted.
- Understanding treatment modalities can guide prognosis and management for similar rare pediatric brain tumors.
Abstract:
The relative frequency of pediatric gliosarcoma (GSM) is 1.9% among glioblastomas and 0.5% among pediatric central nervous system tumors. A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days. Magnetic resonance imaging showed a large heterogeneously enhancing space occupying lesion in the left parieto-occipital region. A parieto-occipital craniotomy with radical excision of tumor was performed. The patient was given adjuvant therapy following surgery and survived until 9 months following surgery. The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.
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