Related Experiment Video
Updated: Apr 7, 2026
12:40
A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
15.3K
Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib
Róbert Pálmason1, Ola Lindén2, Johan Richter1
1Department of Hematology and vascular disorders, Skåne University Hospital, Lund, Sweden ; Lund University, Lund, Sweden.
BMC Hematology
|July 14, 2015
Summary
Ruxolitinib treatment for myelofibrosis may increase the risk of Epstein-Barr virus (EBV) reactivation. This case highlights the need for close patient monitoring for opportunistic infections during Ruxolitinib therapy.
Area of Science:
- Oncology
- Hematology
- Virology
Background:
- Ruxolitinib is a Janus kinase inhibitor approved for myelofibrosis treatment.
- Potential side effects include opportunistic infections and viral reactivations.
- Epstein-Barr virus (EBV) reactivation has not been previously reported with Ruxolitinib.
Observation:
- A 57-year-old female with post-polycythemic myelofibrosis received Ruxolitinib treatment.
- Nine weeks post-treatment, she developed a rapidly fatal CNS lymphoproliferative disorder.
- The disorder was suspected to be EBV-driven.
Findings:
- This case presents a potential association between Ruxolitinib and EBV reactivation.
- The EBV reactivation led to a severe and fatal lymphoproliferative disorder.
Implications:
- Patients on Ruxolitinib require vigilant monitoring for opportunistic pathogens and viral infections.
- Early detection and management of viral reactivations are crucial in Ruxolitinib-treated patients.
- Further research is needed to understand the link between Ruxolitinib and EBV reactivation.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
6.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.6K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.0K
6.0K
01:16Primary Lymphoid Organs
16.8K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.8K
01:15Secondary Lymphoid Organs
10.3K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.3K
01:25Immunodeficiency Diseases
3.1K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
3.1K
01:27Disorders of Leukocytes
2.4K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.4K