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Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with

Romilly E Hodges1, Deanna M Minich2

  • 1University of Bridgeport, 126 Park Avenue, Bridgeport, CT 07748, USA.

Journal of Nutrition and Metabolism
|July 14, 2015
PubMed

Insights

Foods and nutrients can support human detoxification pathways, including Phase I and Phase II enzymes. A whole-foods approach is recommended due to dose-dependent effects and genetic variations influencing outcomes.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Human biotransformation and elimination systems are crucial for detoxification.
  • Detoxification pathways involve Phase I and Phase II enzymes, Nrf2 signaling, and metallothionein.
  • Understanding these systems is key to managing health and disease.

Purpose of the Study:

  • To review current research on how foods and nutrients affect detoxification pathways.
  • To highlight the potential of dietary components in modulating detoxification functions.
  • To explore clinical applications and considerations for improving patient outcomes.

Main Methods:

  • Systematic review of clinical and in vivo studies.
  • Analysis of research on food-derived components and detoxification enzymes.
  • Examination of Nrf2 signaling and metallothionein modulation by nutrients.

Main Results:

  • Evidence suggests foods and nutrients can support or modulate detoxification functions.
  • Potential clinical applications exist for altering detoxification pathway activity.
  • Research indicates biphasic, dose-dependent effects of nutrients and influence of genetic polymorphisms.

Conclusions:

  • Dietary interventions show promise for supporting detoxification.
  • Caution is advised due to research limitations and variable individual responses.
  • A whole-foods approach is suggested for optimizing detoxification support.

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