Related Experiment Video

Updated: Apr 7, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically

Daniel Bia1, Cintia Galli2, Rodolfo Valtuille3

  • 1Physiology Department, School of Medicine, CUiiDARTE, Republic University, 11800 Montevideo, Uruguay.

International Journal of Nephrology
|July 14, 2015
PubMed

Insights

Fluid overload in chronic hemodialysis patients is linked to increased central arterial stiffness. Managing body fluid status is crucial for reducing this stiffness, particularly in the carotid-femoral pathway.

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Chronic hemodialysis patients (CHP) often exhibit high arterial stiffness.
  • Adequate fluid management may be key to mitigating arterial stiffness in CHP.

Purpose of the Study:

  • To investigate the relationship between body fluid status and arterial stiffness in CHP.
  • To differentiate between central and peripheral arterial stiffness in relation to fluid status.

Main Methods:

  • Arterial stiffness measured via pulse wave velocity (PWV) in central (carotid-femoral) and peripheral (carotid-brachial) pathways.
  • Blood pressure-independent regional arterial stiffness index calculated using PWV.
  • Whole-body multiple-frequency bioimpedance used for volume status assessment.
  • Patients categorized into normal, overhydration, and dehydration groups based on fluid status.

Main Results:

  • Central arterial stiffness (carotid-femoral PWV) showed a positive association with hydration status.
  • This association was observed with extracellular/intracellular fluid, extracellular/Total Body Fluid, and overhydration metrics.
  • No significant association was found between fluid status and peripheral arterial stiffness.

Conclusions:

  • Volume status and overload are significantly associated with central arterial stiffness in CHP.
  • This relationship is independent of blood pressure levels.
  • Peripheral arterial stiffness is not significantly associated with volume status in this patient group.

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.6K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

11.4K

Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
588
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.6K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.9K
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.5K