Chikungunya Virus Infection and Acute Elevation of Serum Prostate-Specific Antigen
William Derval Aiken1, Joshua J Anzinger2
1Division of Urology, Section of Surgery, Department of Surgery, Anaesthesia & Intensive Care and Emergency Medicine, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica.
Abstract:
A man with prostate cancer on a regime of active surveillance had a laboratory-confirmed acute Chikungunya virus infection. The patient experienced a sudden increase in serum Prostate-Specific Antigen (PSA) during the acute illness that caused him anxiety and confounded interpretation of the PSA test. Six weeks after the onset of Chikungunya Fever symptoms, the elevated serum PSA returned to baseline. The association of Chikungunya Fever and elevated serum PSA may result in misinterpretation of the PSA test, triggering unnecessary prostate biopsy or other management errors.
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