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Protocol for Isolating the Mouse Circle of Willis
Published on: October 22, 2016
Cerebral aneurysms associated with segmental dilative arteriopathy of the circle of Willis
Yoshifumi Horita1, Takeshi Mikami1, Kiyohiro Houkin2
1Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan.
Insights
This study presents two rare cases of saccular aneurysms linked to dilative arteriopathy in the anterior circulation. Successful surgical clipping resulted in full patient recovery without neurological deficits.
Area of Science:
- Neuroscience
- Vascular Neurology
- Cerebrovascular Diseases
Background:
- Dilative arteriopathy, a form of dolichoectasia, is occasionally seen in the posterior circulation and linked to stroke.
- This condition involves tortuous and elongated arteries, sometimes associated with congenital anomalies.
Observation:
- Two unusual cases of saccular aneurysms associated with segmental dilative arteriopathy in the anterior circulation are reported.
- Case 1: A 39-year-old woman with irregular tortuosity and coiling of the left internal cerebral artery with saccular aneurysms.
- Case 2: A 45-year-old woman with a ruptured saccular aneurysm in the coiling of the anterior cerebral artery.
Findings:
- Both patients underwent successful surgical clipping of the aneurysms.
- Both patients recovered uneventfully with no neurological deficits.
Implications:
- Dilative arteriopathy of the circle of Willis is an uncommon anomaly.
- This report details the first known cases of saccular aneurysms associated with dilative arteriopathy of the circle of Willis in patients without prior medical history.
- Highlights the importance of recognizing and managing this rare cerebrovascular condition.
Background:
Dilative arteriopathy is a form of dolichoectasia. It is sometimes observed in the posterior circulation, and it may be associated with various type of stroke. Herein, we report two unusual cases of saccular aneurysms associated with a segmental dilative arteriopathy located in the anterior circulation.
Case Descriptions:
The first case is a 39-year-old woman with irregular tortuosity and coiling of the left internal cerebral artery along with saccular aneurysms in this artery. The second case is a 45-year-old woman presenting with a ruptured saccular aneurysm in the coiling of the anterior cerebral artery. In both cases, the aneurysm was clipped successfully, and the patients recovered uneventfully with no neurological deficits.
Conclusion:
Dilative arteriopathy of the circle of Willis is an unusual anomaly and is characterized by tortuous and elongated arteries, which are sometimes observed in patients with a congenital anomaly. This report describes two cases of saccular aneurysm associated with dilative arteriopathy of the circle of Willis with no medical history, which to the best of our knowledge has not previously been described.
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