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Advanced Morphological and Functional Magnetic Resonance Techniques in Glaucoma.

Rodolfo Mastropasqua¹, Luca Agnifili², Peter A Mattei²

¹Ophthalmology Unit, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, 37121 Verona, Italy.

Biomed Research International

|July 14, 2015

Summary

Advanced magnetic resonance (MR) techniques may help diagnose glaucoma earlier by detecting changes in the optic nerve and visual cortex. This could lead to earlier intervention for irreversible blindness.

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Area of Science:

Ophthalmology
Neurology
Radiology

Background:

Glaucoma is a leading cause of irreversible blindness, affecting retinal ganglion cells and the posterior visual pathway.
Current diagnosis relies on optic neuropathy signs and visual field alterations, often detected after significant nerve fiber loss.

Purpose of the Study:

To systematically review the potential of advanced magnetic resonance (MR) techniques for earlier glaucoma diagnosis.
To assess if MR imaging can detect modifications in the optic nerve and visual cortex at earlier disease stages.

Main Methods:

Systematic review of studies utilizing advanced MR techniques.
Inclusion of morphometry, diffusion tensor imaging, arterial spin labeling, and functional connectivity.

Main Results:

Advanced MR techniques show promise in identifying subclinical changes associated with glaucoma.
These methods may detect alterations in the optic nerve and visual cortex earlier than traditional methods.

Conclusions:

Advanced MR techniques offer a potential avenue for earlier glaucoma detection.
Further research is warranted to validate these findings for clinical application in diagnosing glaucoma.