Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Cancer Therapies02:49

Cancer Therapies

3.0K
3.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2026
Same author

Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis.

Bone & joint open·2026
Same author

Age-related real-world treatment patterns and outcomes of localised, high-grade osteosarcoma.

Journal of bone oncology·2026
Same author

Deep learning-based auto-contouring for organs at risk in three-dimensional image-guided brachytherapy for cervical cancer and endometrial cancer.

Journal of applied clinical medical physics·2026
Same author

Analysis of the Relationship Between Survival and Postoperative Infection in Patients With Osteosarcoma.

Journal of surgical oncology·2026
Same author

Induction of IL-9-producing CD8<sup>+</sup> T cells by ascochlorin derivatives.

British journal of pharmacology·2026

Related Experiment Video

Updated: Apr 7, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K

Immunotherapy for Bone and Soft Tissue Sarcomas.

Takenori Uehara1, Tomohiro Fujiwara2, Ken Takeda3

  • 1Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan ; Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Biomed Research International
|July 14, 2015
PubMed
Summary
This summary is machine-generated.

Immunotherapies offer new hope for bone and soft tissue sarcomas, showing potential as adjuvant treatments alongside conventional therapies to improve patient survival rates.

More Related Videos

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K

Related Experiment Videos

Last Updated: Apr 7, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Multimodal therapies for bone and soft tissue sarcomas have plateaued in efficacy over the past two decades.
  • Immunotherapies have demonstrated success in treating various advanced cancers.
  • Investigating novel immunotherapeutic strategies is crucial for improving sarcoma patient outcomes.

Purpose of the Study:

  • To review current immunotherapeutic approaches for bone and soft tissue sarcomas.
  • To discuss the potential of these immunotherapies as adjuvant treatments.
  • To highlight emerging immunotherapies and their efficacy in clinical trials.

Main Methods:

  • Review of existing clinical trials and research on immunotherapies for sarcomas.
  • Analysis of different immunotherapy types, including cytokine therapy, vaccinations, and adoptive cell transfer.
  • Examination of immune checkpoint inhibitors like ipilimumab and nivolumab.

Main Results:

  • Cytokine therapies (interleukin-2, interferons) show limited efficacy due to toxicity.
  • Liposomal muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) is approved in Europe as an adjuvant therapy, improving survival.
  • Vaccinations and chimeric antigen receptor T-cell therapies show promise for sarcoma treatment.

Conclusions:

  • Immunotherapies, particularly when used as adjuvant treatments with conventional therapies, hold significant potential for improving bone and soft tissue sarcoma outcomes.
  • Immune checkpoint inhibitors represent a promising area for further investigation in sarcoma treatment.
  • Continued research and clinical trials are essential to fully realize the benefits of immunotherapy in sarcoma care.