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Updated: Apr 7, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Central Macular Thickness in Children with Myopia, Emmetropia, and Hyperopia: An Optical Coherence Tomography Study
Gordon S K Yau1, Jacky W Y Lee2, Tiffany T Y Woo1
1Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong Kong.
Purpose:
To investigate the central macular thickness (CMT) in myopic, emmetropic, and hyperopic Chinese children using Optical Coherence Tomography.
Methods:
168 right eyes of Chinese subjects aged 4-18 were divided into 3 groups based on their postcycloplegic spherical equivalent: myopes (<-1.0 D); emmetropes (≥-1.0 to ≤+1.0 D); and hyperopes (>+1.0 D) and the CMT was compared before/after age adjustment. The CMT was correlated with age, axial length, and peripapillary retinal nerve fibre layer (RNFL).
Results:
The mean CMT was 274.9 ± 50.3 μm and the mean population age was 7.6 ± 3.3 years. The CMT was thickest in the myopes (283.3 ± 57.3 μm, n = 56), followed by the hyperopes (266.2 ± 55.31 μm, n = 60) and then emmetropes (259.8 ± 28.7 μm, n = 52) (all P < 0.0001). When adjusted for age, myopes had a thicker CMT than the other 2 groups (all P < 0.0001) but there was no CMT difference between the emmetropes and hyperopes (P > 0.05). There was no significant correlation between CMT with age, axial length, or peripapillary RNFL (all P ≥ 0.2).
Conclusion:
Chinese children with myopia had a thicker CMT than those with emmetropia or hyperopia. There was no correlation of the CMT with age, axial length, or peripapillary RNFL thickness.

