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Updated: Apr 7, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Regio- and Stereocontrolled Dieckmann Approach to Treprostinil-Inspired, Polycyclic Scaffold For Building Macrocyclic

Srinivas Chamakuri1, Srinvas Jogula1, Prabhat Arya1

  • 1Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus Gachibowli, 500046, Hyderabad, India.

ACS Combinatorial Science
|July 14, 2015
PubMed
Summary

Researchers created a new synthetic method for natural product-like compounds inspired by treprostinil (UT-15). This approach enables the synthesis of diverse macrocyclic compounds with potential for exploring chiral side chains.

Keywords:
Dieckmann cyclizationmacrocyclesnatural-product-inspired scaffoldstreprostinil

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