Related Experiment Video

Updated: Aug 16, 2026

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

[Antibiotic Resistance and Serotype Pattern of Streptococcus pneumoniae Isolated from Children in St. Petersburg in

O S Kalinogorskaya, S S Belanov, M O Volkova

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |July 15, 2015
    PubMed

    Insights

    The 13-valent conjugate vaccine is effective against most Streptococcus pneumoniae strains causing pneumonia and otitis in St. Petersburg. However, high resistance to beta-lactams and macrolides necessitates ongoing surveillance for effective treatment.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Vaccinology

    Context:

    • Streptococcus pneumoniae (pneumococcus) surveillance is crucial for guiding antibiotic therapy and vaccine selection for pneumococcal infections.
    • Pneumococcal infections, including acute otitis media and pneumonia, pose significant public health challenges, particularly in pediatric populations.

    Purpose:

    • To investigate the serotype distribution and antibiotic resistance patterns of Streptococcus pneumoniae isolates in St. Petersburg, Russia.
    • To evaluate the potential effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV13) based on circulating serotypes.
    • To assess the prevalence of resistance to key antibiotic classes among pneumococcal isolates.

    Summary:

    • A study of 250 S. pneumoniae isolates from children in St. Petersburg (2010-2013) revealed that PCV13 covers 86.1% of pneumonia and 86.4% of acute otitis media isolates.
    • High resistance rates were observed for beta-lactams (penicillin, cefotaxime, ceftaroline) and macrolides (erythromycin), with 32.4% and 33.2% of isolates resistant, respectively.
    • No resistance to moxifloxacin was detected, while resistance to tetracycline, co-trimoxazole, and chloramphenicol ranged from 30-50%. Serotypes 19A, 19F, 14, and 6 were frequently associated with antibiotic resistance.

    Impact:

    • The findings support the use of PCV13 for pneumococcal prophylaxis in the studied region due to its broad serotype coverage.
    • The high prevalence of antibiotic resistance highlights the need for careful antibiotic selection in treating pneumococcal infections and underscores the importance of antimicrobial stewardship.
    • Continued surveillance of pneumococcal serotypes and resistance patterns is essential for adapting treatment guidelines and vaccine strategies to combat evolving public health threats.

    More Related Videos

    Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination09:11

    Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

    Published on: September 25, 2014

    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/4306:06

    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

    Published on: September 11, 2020

    Related Concept Videos

    Development of Antibiotic Resistance01:30

    Development of Antibiotic Resistance

    Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
    2.0K
    Atypical Pneumonia01:14

    Atypical Pneumonia

    Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
    49
    Mechanism of Antibiotic Resistance in MRSA01:25

    Mechanism of Antibiotic Resistance in MRSA

    Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
    115
    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
    43