[Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times]

Area of Science:

• Neurology
• Radiology
• Biochemistry

Background:

• Brain infarction diagnosis relies on timely imaging.
• Computed tomography (CT) is a key tool for stroke verification.
• Understanding factors influencing CT visualization timing is crucial for patient outcomes.

Purpose of the Study:

• To investigate the clinical and pathophysiological differences between early and late CT visualization in acute stroke patients.
• To correlate CT visualization timing with stroke severity, mortality, and functional outcomes.
• To explore the role of blood enzymatic spectrum and acid-base balance in delayed CT visualization.

Main Methods:

• Enrolled 221 patients with brain infarction within 3-48 hours of symptom onset.
• Classified patients into "early" visualization (EV) and "late" visualization (LV) groups based on CT timing.
• Analyzed patient demographics, stroke severity, mortality, functional outcomes, blood enzymatic spectrum, and acid-base balance.

Main Results:

• Patients in the LV group (49.8%) exhibited increased stroke severity, mortality, and unfavorable functional outcomes compared to the EV group (50.2%).
• Stroke lesion volume correlated with unfavorable outcomes in the LV group.
• Pathophysiological correlations were observed between blood enzymatic spectrum, acid-base balance, and delayed CT visualization, linked to energy metabolism failure.

Conclusions:

• Late CT visualization of brain infarction is associated with worse clinical outcomes.
• Delayed intracellular energy synthesis stabilization in aerobic and anaerobic glycolysis may explain late lesion visualization.
• These findings highlight the importance of early diagnosis and potential therapeutic targets related to energy metabolism in stroke.