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Cardiovascular disease biomarkers across autoimmune diseases

Joseph Ahearn1, Kelly J Shields1, Chau-Ching Liu1

  • 1Lupus Center of Excellence, Autoimmunity Institute, Department of Medicine, Allegheny Health Network, USA.

Clinical Immunology (Orlando, Fla.)
|July 15, 2015
PubMed

Insights

Patients with autoimmune disease face high risks of cardiovascular disease (CVD). New biomarkers help identify at-risk individuals for better prevention and treatment strategies.

Area of Science:

  • Immunology
  • Cardiology
  • Biomarker Discovery

Background:

  • Autoimmune diseases significantly increase the risk of premature cardiovascular disease (CVD) mortality.
  • Early identification of high-risk patients with autoimmune disorders is crucial for timely intervention and prevention.
  • Current diagnostic tools may not fully capture the complex CVD risk in these populations.

Purpose of the Study:

  • To review recent advancements in cardiovascular disease biomarkers relevant to patients with autoimmune disorders.
  • To highlight the potential clinical utility of these biomarkers for risk stratification and management.
  • To discuss the role of biomarkers in accelerating targeted therapies for CVD in autoimmunity.

Main Methods:

  • Literature review of recent studies on cardiovascular disease biomarkers in autoimmune diseases.
  • Focus on lipid oxidation, imaging biomarkers (coronary calcium, plaque, intima media thickness), inflammation, complement, genetic, endothelial, and antiphospholipid antibody markers.
  • Analysis of the clinical implementation and therapeutic implications of these biomarkers.

Main Results:

  • Emerging biomarkers include lipid oxidation products, imaging assessments of atherosclerosis, inflammatory markers, complement activation products, genetic predispositions, endothelial dysfunction indicators, and antiphospholipid antibodies.
  • These biomarkers offer a more comprehensive approach to assessing CVD risk in autoimmune disease.
  • Successful clinical implementation can improve patient care and drug development.

Conclusions:

  • A panel of diverse biomarkers is essential for accurate identification, monitoring, and stratification of cardiovascular risk in autoimmune disease patients.
  • Implementing these biomarkers can enhance clinical decision-making and personalize treatment strategies.
  • Further research and clinical validation will facilitate the reduction of cardiovascular mortality in individuals with autoimmune conditions.

Keywords:
AtherosclerosisAutoimmuneBiomarkersCardiovascularLupusRheumatoid

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