Related Experiment Video

Updated: Apr 7, 2026

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
11:29

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact

Published on: July 17, 2016

29.0K

Interrelationship between angiogenesis, inflammation and oxidative stress in Indian patients with multiple myeloma

S Joshi1, N Gupta1, R Khan1

  • 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|July 15, 2015
PubMed
Abstract

Insights

This study reveals that elevated angiogenesis and inflammation markers, alongside reduced oxidative stress, are strongly associated with multiple myeloma (MM) progression. These factors collectively create a bone marrow microenvironment conducive to cancer cell growth.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Multiple myeloma (MM) is a bone marrow malignancy driven by clonal plasma cells.
  • The bone marrow microenvironment is shaped by angiogenic factors, proteases, reactive oxygen species, and inflammatory cytokines.
  • Previous research highlighted individual roles of angiogenesis, inflammation, and oxidative stress in MM, but their interplay remains understudied.

Purpose of the Study:

  • To investigate the combined contribution of angiogenesis, inflammation, and oxidative stress to the MM bone marrow microenvironment.
  • To explore the interrelationships between key molecular markers in MM patients.

Main Methods:

  • Circulatory levels of VEGF, angiopoietin-2 (Ang-2), IL-6, and TNF-α were measured.
  • Activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were assessed.
  • Correlation and regression analyses were performed on 62 MM patients and 50 healthy controls.

Main Results:

  • MM patients exhibited higher VEGF, Ang-2, IL-6, and TNF-α levels compared to controls.
  • MM patients showed decreased SOD and GPx activity.
  • A significant association was found between these molecular markers and disease severity.

Conclusions:

  • Angiogenesis, inflammation, and oxidative stress are interconnected in MM.
  • These factors collectively promote the growth, survival, and proliferation of malignant plasma cells within the bone marrow.
  • Understanding this interplay is crucial for developing targeted MM therapies.
Keywords:
AngiogenesisBone marrow microenvironmentInflammationMultiple myelomaOxidative stress

More Related Videos

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K
Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

16.1K

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.2K