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Related Concept Videos

Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

37
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
37

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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Respiratory Pathology and Pathogens in Wild Urban Rats (Rattus norvegicus and Rattus rattus).

J L Rothenburger1, C G Himsworth2, C B Clifford3

  • 1Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada jamie.rothenburger@gmail.com.

Veterinary Pathology
|July 15, 2015
PubMed
Summary
This summary is machine-generated.

Respiratory disease is common in wild urban rats, frequently caused by cilia-associated respiratory bacillus (CARB) and Mycoplasma pulmonis. These infections are linked to increased body mass and may significantly impact rat health and survival.

Keywords:
Mycoplasma pulmonis pathologyPneumocystisRattus norvegicusRattus rattuscilia-associated respiratory bacilluslungratsrespiratory diseaseswild

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Area of Science:

  • Veterinary Pathology
  • Wildlife Disease Ecology
  • Rodent Health

Background:

  • Wild rat populations are ecologically significant but their natural diseases, particularly respiratory conditions, are poorly understood.
  • Norway rats (Rattus norvegicus) and black rats (Rattus rattus) are prevalent urban dwellers.

Purpose of the Study:

  • To describe the gross and histological lesions in the respiratory tracts of wild urban rats.
  • To identify pathogens associated with observed respiratory lesions.
  • To assess the prevalence of specific respiratory pathogens and their correlation with disease indicators.

Main Methods:

  • Gross and histological examination of respiratory tracts from 711 wild urban rats.
  • Histological assessment for 19 distinct lesion categories.
  • Serology and PCR testing for known respiratory pathogens (including cilia-associated respiratory bacillus [CARB] and Mycoplasma pulmonis).

Main Results:

  • Gross lesions were rare (1%), but upper respiratory tract inflammation was prevalent (87%) in examined rats.
  • Lymphoplasmacytic inflammation in the upper and lower respiratory tracts was significantly associated with CARB, M. pulmonis, and increased body mass.
  • Rats were often coinfected with M. pulmonis and CARB, with indistinguishable lesions; Pneumocystis sp was detected but not significantly linked to pathology.

Conclusions:

  • Respiratory disease is a common condition in wild urban rat populations.
  • CARB and M. pulmonis are significant contributors to respiratory pathology in wild rats.
  • The impact of these respiratory diseases on individual and population health warrants further investigation.