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Gold trifluoromethyl complexes.

Juan Gil-Rubio1, José Vicente

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This review covers gold trifluoromethyl complexes, the sole perfluoroalkyl gold compounds. These complexes exhibit unique stability and reactivity, with potential applications in gold-catalyzed trifluoromethylation reactions.

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Area of Science:

  • Organometallic Chemistry
  • Fluorine Chemistry

Background:

  • Gold trifluoromethyl complexes are the only known isolated perfluoroalkyl gold compounds.
  • Research has primarily focused on neutral gold(I) complexes, with fewer examples in gold(II) and gold(III) oxidation states.

Purpose of the Study:

  • To review the synthesis, reactivity, and applications of gold trifluoromethyl complexes.
  • To highlight the unique properties and potential uses of these compounds in catalysis.

Main Methods:

  • Review of existing literature on gold trifluoromethyl complexes.
  • Analysis of synthetic pathways including oxidative addition and transmetallation.
  • Examination of reactivity patterns and catalytic potential.

Main Results:

  • Gold trifluoromethyl complexes display notable thermal stability and strong gold-carbon bonds.
  • Some gold(III) complexes undergo facile reductive elimination, enabling trifluoromethylation.
  • Synthetic methods currently limit the availability of gold(II) and gold(III) trifluoromethyl complexes.

Conclusions:

  • Gold trifluoromethyl complexes possess unique characteristics valuable for synthetic chemistry.
  • Potential exists for developing novel gold-catalyzed trifluoromethylation processes.
  • Further research into synthetic methodologies for higher oxidation states is warranted.