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Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Related Experiment Video

Updated: Apr 7, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Soft microcapsules with highly plastic shells formed by interfacial polyelectrolyte-nanoparticle complexation.

Gilad Kaufman¹, Siamak Nejati, Raphael Sarfati

¹Department of Chemical and Environmental Engineering, Yale University, New Haven, CT 06511, USA. Chinedum.Osuji@yale.edu.

|July 15, 2015

Summary

This summary is machine-generated.

Researchers developed a novel single-step method for creating composite microcapsules using nanoparticle-polyelectrolyte and protein-polyelectrolyte complexes. This approach offers controlled mechanical and release properties for advanced applications.

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Published on: October 13, 2021

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Area of Science:

Materials Science
Biomaterials Engineering
Nanotechnology

Background:

Composite microcapsules are crucial for biomedical applications.
Conventional fabrication methods are often multi-step and time-consuming.

Purpose of the Study:

To present a novel single-step fabrication method for composite microcapsules.
To demonstrate control over the mechanical and release properties of these microcapsules.

Main Methods:

Fabrication of microcapsules via interfacial complexation of nanoparticle-polyelectrolyte and protein-polyelectrolyte across a water-oil droplet interface.
Characterization of shell thickness (few μm).
Assessment of mechanical properties (plastic vs. elastic response) using micropipette aspiration.

Main Results:

Successful single-step fabrication of composite microcapsules.
Silica shell microcapsules showed significant plastic deformation.
Lysozyme-incorporated shells exhibited a more elastic response.
Exploitation of shell plasticity to create high aspect ratio protrusions.

Conclusions:

The single-step method provides an efficient route to tunable composite microcapsules.
The distinct mechanical properties of nanoparticle and protein-based shells offer versatile design possibilities.
This technique enables the creation of complex microcapsule architectures for tailored applications.