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Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

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Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Apr 7, 2026

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
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High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

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Improving customized fetal biometry by longitudinal modelling.

Scott W White1,2,3, Julie A Marsh4, Stephen J Lye5

  • 1a School of Women's and Infants' Health, The University of Western Australia , Perth , Western Australia , Australia .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 15, 2015
PubMed
Summary

Customized fetal biometric charts improve detection of abnormal fetal growth. These charts offer better accuracy than population-derived charts, potentially reducing unnecessary interventions and improving pregnancy management.

Keywords:
Biometric trajectoriesRaine studycustomizationfetal growth

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Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Biostatistics

Background:

  • Accurate assessment of fetal growth is crucial for optimal pregnancy management.
  • Population-derived fetal biometric charts may not adequately account for individual variations.
  • Deviations from optimal fetal growth can indicate potential complications.

Purpose of the Study:

  • To develop customized fetal biometric charts for improved detection of abnormal fetal growth.
  • To compare the accuracy of customized charts against population-derived charts.
  • To evaluate the impact of customized charts on identifying growth deviations.

Main Methods:

  • Serial ultrasound biometry (abdominal circumference, head circumference, femur length) was performed on 1056 fetuses.
  • Customized biometry trajectories were developed, adjusting for epidemiological influences using covariates from 18 weeks' gestation.
  • Prediction accuracy was assessed using receiver operating characteristic curves and cross-validation.

Main Results:

  • Customized charts demonstrated good performance in predicting estimated fetal weight extremes (AUCs ~0.70).
  • Fetal abdominal circumference prediction was accurate for growth restriction and macrosomia (AUCs ~0.79).
  • Population charts misclassified 7.9% of small and 10.7% of large fetuses as normal, while customized charts identified more accurately.

Conclusions:

  • Customized fetal biometric charts enhance the ability to detect deviations from optimal fetal growth.
  • These charts may lead to more precise pregnancy management and potentially reduce unnecessary interventions.
  • Improved detection of abnormal fetal growth can positively influence clinical decision-making.