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Updated: Apr 7, 2026

Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition
Published on: May 17, 2024
Characterization of Carbohydrate Vaccines by NMR Spectroscopy
Francesco Berti1, Neil Ravenscroft
1Research, GSK Vaccines, Via Fiorentina 1, 53100, Siena, Italy, francesco.x.berti@gsk.com.
Abstract:
Physicochemical techniques are a powerful tool for the structural characterization of carbohydrate-based vaccines. High-field Nuclear Magnetic Resonance (NMR) spectroscopy has been established as an extremely useful and robust method for tracking the industrial manufacturing process of these vaccines from polysaccharide bulk antigen through to the final formulation. Here, we describe the use of proton NMR for structural identity and conformity testing of carbohydrate-based vaccines.
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